Multiscale imaging for knee arthritis
The most common joint disease is the arthritis, a condition that affects 10 million patients in France. Arthritis diminishes the quality of life and its direct and indirect costs keep increasing as the population ages. The B2OA is particularly interested by the osteoarthritis (OA), which the annual incidence is 240/100,000. The most common methods for OA diagnosis of the knee are radiography and magnetic resonance imaging (MRI), with the MRI being mostly used by research teams. The radiography is a 2D projection of a complex 3D structure, and is therefore rather insensitive only allowing the diagnosis of OA in the late stages of the disease.
We propose, with the use of an algorithm, to obtain a surface reconstruction of the joint. This numerical image will allow us to identify biomarkers focused on the modification of bone shape and joint space narrowing. At the same time, we collaborate with the CEA List and Thal├Ęs Electronic Device to develop next-generation scanners of type "Cone Beam Computed Tomography", which are scanners with low radiations and costs dedicated to osteoarticular tissues.
Scanner images of a knee
The knee joint is a functional unit and in order to better understand the interactions between cartilage and subchondral bone we use multiscale 3D scanner imaging (clinical scanner, high resolution scanner device, micrometric scanner). This approach also allows us to validate, better understand et interpret biomarkers such as bone texture of the subchondral bone in healthy and diseased patients.

  • Understanding the role of the subchondral bone in the pathogenesis of OA 
  • Study of the architecture of the subchondral bone by quantitative tomodensitometry (QCT; 400 micron resolution) in vivo and application of dedicated 3D software allowing the selection of region of interest. Study of bone density and texture parameters 
  • Comparison of architectural parameters obtained with extreme CT (pQCT; 80 micron resolution) or micro-scanner (10 micron resolution) 
  • Comparison of results from healthy subjects and patients at different stages of OA 

Our collaborators:
Research areas
Bioimaging of osteo-articular tissues
Multiscale imaging for knee arthritis