Morad Bensidhoum

Position: Senior Researcher
Administrative attachment: CNRS

Leader of "Fundamental aspects of osteoarticular repair" research axis

Expertise

  • Bone tissue engineering
  • Molecular/cellular biology, histology/histomorphometry, X-ray imaging
  • Animal/cellular models
  • Bone cell therapy /Biology of MSCs derived bone marrow / Scaffold and materials

Curriculum Vitae

2007-present: CNRS Senior Researcher
2017: Habilitation to direct research (HDR) - University Paris Diderot Title: From nucleic acid to tissue engineering
2004-2006: Post-doctoral fellow, Service de Génomique fonctionnelle du CEA.
2003-2004: Post-doctoral fellow, CHU St Antoine Paris
1998-2003: Post-doctoral fellow CHU St Antoine (Paris) & IRSN (Fontenay aux Roses 92).
1997: PhD – University Bordeaux 2. Mention: Biological and Medical Science - Option: Biology – Health. Title: Molecular analysis of patients with congenital erythropoietic porphyria and development of a mouse model of the disease for gene therapy

Selected publications

Caliaperoumal G, Souyet M, Bensidhoum M, Petite H, Anagnostou F.  Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats. Bone. 2018 Jul;112:161-172. Link for the publication .
Oudina K, Paquet J, Moya A, Massourides E, Bensidhoum M, Larochette N, Deschepper M, Pinset C, Petite H. The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model. Sci Rep. 2018 Nov 20;8(1):17106. Link for the publication .
Martinod E, Chouahnia K, Radu DM, Joudiou P, Uzunhan Y, Bensidhoum M, Santos Portela AM, Guiraudet P, Peretti M, Destable MD, Solis A, Benachi S, Fialaire-Legendre A, Rouard H, Collon T, Piquet J, Leroy S, Vénissac N, Santini J, Tresallet C, Dutau H, Sebbane G, Cohen Y, Beloucif S, d'Audiffret AC, Petite H, Valeyre D, Carpentier A, Vicaut E. Feasibility of Bioengineered Tracheal and Bronchial Reconstruction Using Stented Aortic Matrices. JAMA. 2018 Jun 5;319(21):2212-2222. Link for the publication .
Paquet J, Moya A, Bensidhoum M, Petite H. Engineered cell-free scaffold with two-stage delivery of miRNA-26a for bone repair. Ann Transl Med. 2016 May;4(10):204. Link for the publication .
Becquart P, Cruel M, Hoc T, Sudre L, Pernelle K, Bizios R, Logeart-Avramoglou D, Petite H, Bensidhoum M. Human mesenchymal stem cell responses to hydrostatic pressure and shear stress. Eur Cell Mater. 2016 Feb 19;31:160-73. Link for the publication .
Cruel M, Bensidhoum M, Nouguier-Lehon C, Dessombz O, Becquart P, Petite H, Hoc T. Numerical Study of Granular Scaffold Efficiency to Convert Fluid Flow into Mechanical Stimulation in Bone Tissue Engineering. Tissue Eng Part C Methods. 2015 Sep;21(9):863-71. Link for the publication .
Manassero M, Viateau V, Deschepper M, Oudina K, Logeart-Avramoglou D, Petite H, Bensidhoum M. Bone regeneration in sheep using acropora coral, a natural resorbable scaffold, and autologous mesenchymal stem cells. Tissue Eng Part A. 2013 Jul;19(13-14):1554-63. Link for the publication .
Deschepper M, Oudina K, David B, Myrtil V, Collet C, Bensidhoum M, Logeart-Avramoglou D, Petite H. Survival and function of mesenchymal stem cells (MSCs) depend on glucose to overcome exposure to long-term, severe and continuous hypoxia. J Cell Mol Med. 2011 Jul;15(7):1505-14. Link for the publication .
Bensidhoum M, Gobin S, Chapel A, Lemaitre G, Bouet S, Waksman G, Thierry D, Martin MT. Therapeutic effect of human mesenchymal stem cells in skin after radiation damage [French]. J Soc Biol. 2005;199(4):337-41
Bensidhoum M, Chapel A, Francois S, Demarquay C, Mazurier C, Fouillard L, Bouchet S, Bertho JM, Gourmelon P, Aigueperse J, Charbord P, Gorin NC, Thierry D, Lopez M. Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment. Blood. 2004 May 1;103(9):3313-9. Link for the publication .
Neildez-Nguyen TM, Wajcman H, Marden MC, Bensidhoum M, Moncollin V, Giarratana MC, Kobari L, Thierry D, Douay L. Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo. Nat Biotechnol. 2002 May;20(5):467-72. Link for the publication .

PubMed link for M. Bensidhoum's publications

Contact

+33 (0)1 57 27 85 39