Defended by Jonathan RIBOT on 15-12-2015
Diabetes is a disease associated with a bad functioning of glucose metabolism and represents a major health issue. The majority of diabetic are type 2 diabetic patients.Main complications in diabetes are vascular. Diabetic patients have paradoxical angiogenesis pathologies. Microangiopathy which occurs during diabetes modifies the microenvironment of bone marrow and lead to problem of wound healing whereas exacerbate angiogenesis is responsible for pathologies such as diabetic retinopathy or nephropathy.Mesenchymal stem cells (MSCs) are known for their differentiation potential and their release of bioactive mediators which are involved in tissular regeneration. The mechanism associated with microenvironment and functions of MSCs in a diabetic context remain elusive. Diabetes can change the characteristics of MSCs and diabetic microenvironment can lead to modifications in functionality of transplanted MSCs as well as modifying their autocrine/paracrine capacity on surrounding cells. The study of diabetic MSCs potential and the diabetic microenvironment on MSCs could have major clinical implications. The primary objective of this study was to characterize the impact of diabetes on functionality and angiogenic potential of MSCs with the help of a rat model, the Zucker Diabetic Fatty (ZDF) which develop spontaneously diabetes type 2 and the whole vascular complication associated with it.
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